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3-Aminobenzonitrile → 4-(3-Cyanophenylamino)-3-ethoxycarbonyl-5,8-difluoroquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Aminobenzonitrile | HCID 16702 | — |
| 反応物 | Ethyl 4-chloro-5,8-difluoroquinoline-3-carboxylate | HCID 17040076 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 4-(3-Cyanophenylamino)-3-ethoxycarbonyl-5,8-difluoroquinoline | HCID 19032474 | 50.3% |
反応手順
The reaction mixture of 106.0 mg (0.37 mmol) of 4-chloro-3-ethoxycarbonyl-5,8-difluoroquinoline and 51.5 mg (0.44 mmol) of 3-amino-benzonitrile in 2.0 mL of 2-propanol was refluxed for 2 h and cooled down. The pale yellow precipitate was filtered, washed with cold 2-propanol, and dried in oven at 40° C. overnight to give 65.7 mg (50%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05650415 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-08c6b9fd12f343c2aa39b211df1c0510 |
| 出典メモ | uspto-grants-1997_07 |