関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-Bromoaniline | HCID 11562 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Ethyl 4-chloro-6-(trifluoromethyl)quinoline-3-carboxylate | HCID 4322147 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(3-Bromophenylamino)-3-ethoxycarbonyl-6-trifluoromethylquinoline | HCID 19032481 | — |
反応手順
The reaction mixture of 270.0 mg of 4-chloro-3-ethoxycarbonyl-6-trifluoromethylquinoline and 150 mL of 3-bromoaniline in 4 mL ethanol was heated at 95° C. for 4 h. The reaction was then cooled in an ice-water bath and addid with 2 mL of 0.5N sodium hydroxide solution. The solid was filtered, washed with cold ethaol-water (2:1) and dried to provide 278.0 mg of the titled compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05650415 |
|---|
| 出典データセット | uspto-grants-1997_07 |
|---|
| ORD ID | ord-47f0e2a705654b17855c3ae306d058a5 |
|---|
| 出典メモ | uspto-grants-1997_07 |
|---|
