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Benzoyl chloride → 8-Chloro-2-(n-propylbenzoyl)amino-1,2,3,4-tetrahydronaphthalene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoyl chloride | HCID 7412 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 8-chloro-2-(N-n-propylamino)tetralin | HCID 14969229 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 8-Chloro-2-(n-propylbenzoyl)amino-1,2,3,4-tetrahydronaphthalene | HCID 19032662 | 95% |
反応手順
To a solution of 53g (0.23 mol) 8-chloro-2-(n-propyl)amino-1,2,3,4-tetrahydronaphthalene and 50 ml triethylamine in 500 ml dichloromethane was added dropwise 33 ml (40 g, 0.28 mol) benzoylchloride. After stirring over night at room temperature, 10% sodium carbonate was added and the mixture was shaken and separated. The organic phase was dried (magnesium sulphate), filtered and evaporated yielding 72 g (95%) raw product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05650427 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-cf8aa99e853643b3a98d70a16e3826d6 |
| 出典メモ | uspto-grants-1997_07 |