Acetic Acid → [4-(2-Bromoethyl)phenyl]acetic acid

HRID 26619ノート

反応式

HRID 26619 の反応式
[Br:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7](CC#N)=[CH:6][CH:5]=1.[C:13]([OH:16])(=[O:15])[CH3:14]>Br>[Br:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:14][C:13]([OH:16])=[O:15])=[CH:6][CH:5]=1

参加物

4

反応物 2

HCID 176Acetic AcidHCID 20386067HCID 20386067、化合物

生成物 1

HCID 20386065[4-(2-Bromoethyl)phenyl]acetic acid

試薬・触媒・溶媒 1

HCID 260Hydrogen Bromide溶媒

実験手順

A solution of [4-(2-bromoethyl)phenyl]acetonitrile (56.0 g., 0.25 mole) in 48% hydrobromic acid (200 ml.) and acetic acid (600 ml.) is boiled under reflux for 4 hours. The solution is reduced to one-third volume by distillation at reduced pressure. The residue is diluted with 400 ml. of water to force out the oily product which is taken up in ether, washed with water, and dried over sodium sulfate. Evaporation of the solvent leaves the title compound as a residual oil.

後処理

  1. temperatureunder reflux for 4 hours
  2. distillationThe solution is reduced to one-third volume by distillation at reduced pressure
  3. additionThe residue is diluted with 400 ml
  4. washwashed with water
  5. dry with materialdried over sodium sulfate
  6. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-26a2cdde76624980b19243533ed01893
出典データセット
uspto-grants-1979_04
特許番号
US04150235

反応ノート

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