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Water ethanol → 2-(1-Phenyltetrazol-5-yl)thiomethyl-4-isopropyl-5,6-dimethoxy-saccharin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water ethanol | HCID 19096565 | — |
| 反応物 | 2-Chloromethyl-4-isopropyl-5,6-dimethoxysaccharin | HCID 70044954 | — |
| 反応物 | HCID 178527989 | HCID 178527989 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(1-Phenyltetrazol-5-yl)thiomethyl-4-isopropyl-5,6-dimethoxy-saccharin | HCID 44341378 | 51% |
反応手順
By the method of Example 44 condensation of 2-chloromethyl-4-isopropyl-5,6-dimethoxysaccharin (1.46 g) and 1-phenyltetrazol-5-thiol sodium salt (0.92 g) in dimethylformamide (5 mL) and recrystallization of the product from ethanol-water afforded 2-(1-phenyltetrazol-5-yl)thiomethyl-4-isopropyl-5,6-dimethoxy-saccharin, 1.05 g, 51% yield, mp 69°-71° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05650422 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-e185b931be7a4eaeafe033a24efcddd3 |
| 出典メモ | uspto-grants-1997_07 |