Sodium Hydroxide → 2-(Dimethoxyphosphoryl)acetic acid

HRID 26654

反応式

HRID 26654 の反応式
C[O:2][C:3](=[O:11])[CH2:4][P:5]([O:9][CH3:10])([O:7][CH3:8])=[O:6].[OH-].[Na+]>>[CH3:8][O:7][P:5]([CH2:4][C:3]([OH:11])=[O:2])([O:9][CH3:10])=[O:6]

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 80029Trimethyl phosphonoacetate

生成物 1

HCID 1899642-(Dimethoxyphosphoryl)acetic acid

実験手順

Methyl(dimethoxyphosphinyl)acetate (18.2 g., 0.1 mole) and 1 N sodium hydroxide (100 ml., 0.1 mole) are combined and stirred at room temperature overnight. The reaction mixture is poured onto AG50W-X2 cation exchange resin (200 ml.) and eluted with double distilled water. The acidic fractions are combined and concentrated in vacuo. The residue is dissolved in dichloromethane, dried over magnesium sulfate and concentrated in vacuo to yield 16.8 g. of product, (dimethoxyphosphinyl)acetic acid, yield quantitative.

後処理

  1. additionThe reaction mixture is poured onto AG50W-X2 cation exchange resin (200 ml.)
  2. washeluted
  3. distillationwith double distilled water
  4. concentrationconcentrated in vacuo
  5. dissolutionThe residue is dissolved in dichloromethane
  6. dry with materialdried over magnesium sulfate
  7. concentrationconcentrated in vacuo
  8. customto yield 16.8 g

出典と根拠

ORDレコード
ord-2672bbd3dffc45ccad4d00207786c751
出典データセット
uspto-grants-1979_04
特許番号
US04151172

関連ノート

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