Ethylene Oxide → 1-(2-Hydroxyethyl)-4-(N-propionylanilino)piperidine
反応式
[CH2:1]1[O:3][CH2:2]1.[C:4]([N:8]([CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:7])[CH2:5][CH3:6]>C1(C)C=CC=CC=1.CO>[OH:3][CH2:2][CH2:1][N:18]1[CH2:17][CH2:16][CH:15]([N:8]([C:4](=[O:7])[CH2:5][CH3:6])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:20][CH2:19]1参加物
5
反応条件
- 温度
- 15 °C
実験手順
A solution, cooled to 15° C., containing 100 mmol of ethylene oxide in toluene is added slowly to 100 mmol of 4-(N-propionylanilino)piperidine in solution in 100 ml of anhydrous methanol cooled to 15° C. After returning to room temperature and removal of the azeotrope formed by distillation, the expected product is obtained after evaporation to dryness.