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Piperidine → N-phenyl beta-(8-hydroxy-5-quinolyl)-alpha-cyanoacrylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | Acetamide, 2-cyano-N-phenyl- | HCID 69296 | — |
| 反応物 | 8-Hydroxyquinoline-5-carbaldehyde | HCID 275363 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-phenyl beta-(8-hydroxy-5-quinolyl)-alpha-cyanoacrylamide | HCID 54517088 | 75% |
反応手順
A solution of 8-hydroxy-5-quinolinecarboxaldehyde (1.732 g, 0.010 mol), N-phenyl cyanoacetamide (1.602 g, 0.010 mol) and piperidine (0.255 g, 0.003 mol) in absolute ethanol (50 ml) was heated for 3 h at reflux. The reaction mixture was chilled to about 10°-15° C., the precipitate filtered, the residue washed with ice-cooled ethanol and dried under vacuum. Almost pure title compound was obtained in about 75% yield (2.365 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05652250 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-ca1bb5d3581b40c3be74bfd295d6c6c7 |
| 出典メモ | uspto-grants-1997_07 |