反应详情

A solution of 8-hydroxy-5-quinolinecarboxaldehyde (1.732 g, 0.010 mol), N-phenyl cyanoacetamide (1.602 g, 0.010 mol) and piperidine (0.255 g, 0.003 mol) in absolute ethanol (50 ml) was heated for 3 h at reflux. The reaction mixture was chilled to about 10°-15° C., the precipitate filtered, the residue washed with ice-cooled ethanol and dried under vacuum. Almost pure title compound was obtained in about 75% yield (2.365 g).

1. temperatureat reflux
2. temperatureThe reaction mixture was chilled to about 10°-15° C.
3. filtrationthe precipitate filtered
4. washthe residue washed with ice-
5. temperaturecooled ethanol
6. customdried under vacuum