2-Nitroimidazole → (S)-(+)-alpha-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol
反応式
[N+:1]([C:4]1[NH:5][CH:6]=[CH:7][N:8]=1)([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].[CH2:15]([C@H:17]1[O:19][CH2:18]1)[Cl:16]>>[Cl:16][CH2:15][C@@H:17]([OH:19])[CH2:18][N:5]1[CH:6]=[CH:7][N:8]=[C:4]1[N+:1]([O-:3])=[O:2]参加物
4
実験手順
Alternatively, a mixture of 2-nitroimidazole, anhydrous potassium carbonate, and (S)-(+)-epichlorohydrin is refluxed for 10 minutes then filtered while hot. The filtrate is concentrated and cooled to give a solid. Crystallization from ethanol and further processing gives the product.
後処理
- temperatureis refluxed for 10 minutes
- filtrationthen filtered while hot
- concentrationThe filtrate is concentrated
- temperaturecooled
- customto give a solid
- customCrystallization from ethanol and further processing
- customgives the product
出典と根拠
- ORDレコード
- ord-8b9f44a2c47945cba8d44e8530187c1a
- 出典データセット
- uspto-grants-1997_07
- 特許番号
- US05652255
反応ノート
読み込み中…