Oxalyl chloride → 4-[(4-Pyridyl)piperazin-1-yl]benzoyl chloride

HRID 266730

反応式

HRID 266730 の反応式
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[N:7]1[CH:12]=[CH:11][C:10]([CH:13]2[CH2:18][NH:17][CH2:16][CH2:15][N:14]2[C:19]2[CH:27]=[CH:26]C(C(O)=O)=[CH:21][CH:20]=2)=[CH:9][CH:8]=1>ClCCl.CN(C=O)C>[N:7]1[CH:8]=[CH:9][C:10]([CH:13]2[CH2:18][NH:17][CH2:16][CH2:15][N:14]2[C:19]2[CH:27]=[CH:26][C:1]([C:2]([Cl:4])=[O:3])=[CH:21][CH:20]=2)=[CH:11][CH:12]=1

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 189183004-((4-Pyridyl)piperazin-1-yl)benzoic acid

生成物 1

HCID 189183644-[(4-Pyridyl)piperazin-1-yl]benzoyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

Oxalyl chloride (0.5 ml) was added to a stirred suspension of 4-((4-pyridyl)piperazin-1-yl)benzoic acid in dichloromethane (15 ml), followed by DMF (1 drop). The mixture was stirred for 2 hours and evaporated to dryness to give 4-[(4-pyridyl)piperazin-1-yl]benzoyl chloride which was used immediately.

後処理

  1. customevaporated to dryness

出典と根拠

ORDレコード
ord-5fc6cac3a22a4296b8cc0cb66abd3fb2
出典データセット
uspto-grants-1997_07
特許番号
US05652242

関連ノート

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