Allyl bromide → 3-Allyloxycarbonyl-5-nitrobenzoic acid

HRID 266847

反応式

HRID 266847 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:13]([OH:15])=[O:14])[CH:7]=[C:8]([CH:12]=1)[C:9]([OH:11])=[O:10])([O-:3])=[O:2].[CH2:16](Br)[CH:17]=[CH2:18]>>[CH2:18]([O:14][C:13]([C:6]1[CH:7]=[C:8]([CH:12]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)[C:9]([OH:11])=[O:10])=[O:15])[CH:17]=[CH2:16]

参加物

3

反応物 2

HCID 7841Allyl bromideHCID 120695-Nitroisophthalic acid

生成物 1

HCID 206558603-Allyloxycarbonyl-5-nitrobenzoic acid

実験手順

5-Nitroisophthalic acid (5 g) was converted to the mono allyl ester using one equivalent of allyl bromide (2 ml) using a similar method to that described in example 1. The required acid (2.7 g) was extracted from the organic phase with aqueous NaHCO3. The organic layer contained the di-allyl ester (2.7 g). The mono acid, 3-allyloxycarbonyl-5-nitrobenzoic acid, was obtained as a white solid. Nmr (CDCl3): 4.87 (d, 2H); 5.3-5.5 (q, 2H); 5.97-6.15 (m, 1H); 9.01 (t, 3H).

後処理

  1. extractionThe required acid (2.7 g) was extracted from the organic phase with aqueous NaHCO3

出典と根拠

ORDレコード
ord-f3bdd4fedad645b091ab60d0d8d31e33
出典データセット
uspto-grants-1997_07
特許番号
US05652233

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