1-Fluoro-4-nitronaphthalene → 4-Fluoronaphthalen-1-amine
反応式
[F:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([N+:12]([O-])=O)=[CH:4][CH:3]=1>CCOC(C)=O.[Pd]>[F:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([NH2:12])=[CH:4][CH:3]=1参加物
4
実験手順
4-Fluoro-1-nitro-naphthalene (1 g) was dissolved in EtOAc (20 mL) and placed into a hydrogenating flask containing Palladium on activated charcoal (10%, 0.3 g). The reaction mixture was hydrogenated at 50 psi for 5 hr. During the reaction, the pressure of the hydrogen dropped due to the consuming of the hydrogen, and it was brought back to 50 psi a few times. Finally, the reaction stopped when all the starting material was used. The resulting solution was filtered through a pad of celite and washed with EtOAc (20 mL). The clear filtrate was concentrated and dried under vacuum to yield 4-Fluoro-1-aminonaphthalene.
後処理
- customplaced into a hydrogenating flask
- customDuring the reaction
- customthe pressure of the hydrogen dropped due to the consuming of the hydrogen, and it
- filtrationThe resulting solution was filtered through a pad of celite
- washwashed with EtOAc (20 mL)
- concentrationThe clear filtrate was concentrated
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-3487040c7d894b0e9df3b1dbab112100
- 出典データセット
- uspto-grants-1997_07
- 特許番号
- US05652269
反応ノート
読み込み中…