Bromine → 2-Bromo-1-[1-(2-naphthyl)cyclobutyl]ethanone

HRID 266868ノート

反応式

HRID 266868 の反応式
[Br:1]Br.[CH:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[C:13]1([C:17](=[O:19])[CH3:18])[CH2:16][CH2:15][CH2:14]1>C(Cl)(Cl)Cl.CO>[Br:1][CH2:18][C:17]([C:13]1([C:4]2[CH:5]=[CH:6][C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[CH:3]=2)[CH2:16][CH2:15][CH2:14]1)=[O:19]

参加物

5

反応物 2

HCID 24408BromineHCID 21258447HCID 21258447、化合物

生成物 1

HCID 212584952-Bromo-1-[1-(2-naphthyl)cyclobutyl]ethanone

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6212Chloroform溶媒2 回

実験手順

A solution of bromine (4.3 ml) in chloroform (20 ml) was added dropwise over 30 minutes at 10°-15° C. to a stirred solution of 1-[1-(2-naphthyl)cyclobutyl]-ethanone (20 g) in a mixture of methanol (20 ml) and chloroform (30 ml). The mixture was then stirred at ambient temperature for 1.5 hours, poured onto ice-water (300 ml) and the product extracted into dichloromethane (3×150 ml). The extracts were washed with saturated aqueous sodium hydrogen carbonate solution, then water, dried over calcium chloride and the solvent removed in vacuo to give 2-bromo-1-[1-(2-naphthyl)cyclobutyl]-ethanone as an oil (24.0 g).

後処理

  1. additionpoured onto ice-water (300 ml)
  2. extractionthe product extracted into dichloromethane (3×150 ml)
  3. washThe extracts were washed with saturated aqueous sodium hydrogen carbonate solution
  4. dry with materialwater, dried over calcium chloride
  5. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-f93d5d070a3b465e9a77513f2f87ddd5
出典データセット
uspto-grants-1997_07
特許番号
US05652271

反応ノート

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