2-Methoxy-3-nitropyridine → 3-Amino-2-methoxypyridine

HRID 266918

反応式

HRID 266918 の反応式
[CH3:1][O:2][C:3]1[C:8]([N+:9]([O-])=O)=[CH:7][CH:6]=[CH:5][N:4]=1>C(O)C.[Pd]>[CH3:1][O:2][C:3]1[C:8]([NH2:9])=[CH:7][CH:6]=[CH:5][N:4]=1

参加物

4

反応物 1

HCID 2532192-Methoxy-3-nitropyridine

生成物 1

HCID 27374883-Amino-2-methoxypyridine収率 112%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of the compound of Example 12 (17.12 g, 0.11 mol) in ethanol (180 mL) in a Parr bottle, was added 4% Pd/C (3.43 g). The bottle was sealed, purged with nitrogen and was pressurized (5 psi) with hydrogen. After stirring at room temperature for 2 hr, the reaction vessel was vented, purged with nitrogen and filtered. The clear filtrate was concentrated to give the title compound (15.3 g, 90%). 1H NMR (CDCl3): 7.58 (dd, J=5, 2 Hz, 1H); 6.87 (dd, J=8, 2 Hz, 1H); 6.72 (dd, J=8, 5 Hz, 1H); 3.98 (s, 3H).

後処理

  1. customThe bottle was sealed
  2. custompurged with nitrogen
  3. custompurged with nitrogen
  4. filtrationfiltered
  5. concentrationThe clear filtrate was concentrated

出典と根拠

ORDレコード
ord-2fc07f81f427453c919067679c441c9b
出典データセット
uspto-grants-1997_07
特許番号
US05652363

関連ノート

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