Formic Acid → 5-Nitrobenzimidazole

HRID 26704

反応式

HRID 26704 の反応式
[CH:1](O)=O.[N+:4]([C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[C:9]([NH2:14])[CH:8]=1)([O-:6])=[O:5].[OH-].[NH4+]>Cl>[CH:12]1[C:7]([N+:4]([O-:6])=[O:5])=[CH:8][C:9]2[NH:14][CH:1]=[N:13][C:10]=2[CH:11]=1

参加物

5

反応物 3

HCID 284Formic AcidHCID 14923Ammonium HydroxideHCID 51117914-Nitro-1,2-phenylenediamine

生成物 1

HCID 71955-Nitrobenzimidazole収率 89%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

反応条件

温度
80 °C

実験手順

15 ml of formic acid were added to a suspension of 15.3 g of 4-nitro-1,2-phenylenediamine in 150 ml of 10% hydrochloric acid and the mixture was stirred on a water bath at 80° C. for 3 hours and was cooled. The mixture was made alkaline with concentrated ammonium hydroxide solution and the mixture was filtered. The yellowish needles were washed with water and dried over P2O5 under reduced pressure to obtain 14.3 g (89% yield) of 5(6)-nitro-benzimidazole melting at 209°-211° C.

後処理

  1. temperaturewas cooled
  2. filtrationthe mixture was filtered
  3. washThe yellowish needles were washed with water
  4. dry with materialdried over P2O5 under reduced pressure

出典と根拠

ORDレコード
ord-ad13d81e56da485d8fb7cb2484db1443
出典データセット
uspto-grants-1979_04
特許番号
US04151280

関連ノート

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