N2 (benzyloxycarbonyl)-N1-isopentyl-L-prolinamide → HCID 57053150、化合物

HRID 267102ノート

反応式

HRID 267102 の反応式
N#N.C(OC([C@@:13]1([C:23]([NH2:25])=[O:24])[CH2:17][CH2:16][CH2:15][N:14]1[CH2:18][CH2:19][CH:20]([CH3:22])[CH3:21])=O)C1C=CC=CC=1>C(O)C.[Pd]>[CH2:18]([N:14]1[CH2:15][CH2:16][CH2:17][C@H:13]1[C:23]([NH2:25])=[O:24])[CH2:19][CH:20]([CH3:22])[CH3:21]

参加物

4

反応物 1

HCID 86746219N2 (benzyloxycarbonyl)-N1-isopentyl-L-prolinamide

生成物 1

HCID 57053150HCID 57053150、化合物収率 111.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of 5.73 g of N2 -(benzyloxycarbonyl)-N1 -isopentyl-L-prolinamide in 600 ml of ethanol was hydrogenated over 0.8 g of 10% palladium-on-carbon catalyst for 3.75 hours. The catalyst was removed by filtration and the filtrate was evaporated to give 3.4 g of N1 -isopentyl-L-prolinamide as an oil which was used without further purification.

後処理

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-43661b1651e143778e9b71bf14d20eb2
出典データセット
uspto-grants-1997_07
特許番号
US05652369

反応ノート

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