Thionyl Chloride → HCID 21434993、化合物

反応式

[Cl:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:17])[C:7]([C:14](O)=[O:15])=[CH:8][N:9]2[CH2:12][CH3:13])=[CH:4][CH:3]=1.S(Cl)([Cl:20])=O>>[Cl:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:17])[C:7]([C:14]([Cl:20])=[O:15])=[CH:8][N:9]2[CH2:12][CH3:13])=[CH:4][CH:3]=1

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 12801674HCID 12801674、化合物

生成物 1

HCID 21434993HCID 21434993、化合物

実験手順

7-Chloro-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (29.5 g) and thionyl chloride (18 ml) in dry doluene (900 ml) were stirred and heated under reflux for 1 hour. The solution was cooled and the solid that separated was collected. It had m.p. 186.5°-188.5° (98%).

後処理

temperatureheated
temperatureunder reflux for 1 hour
temperatureThe solution was cooled
customthe solid that separated
customwas collected

出典と根拠

ORDレコード: ord-697003830a5e49b69947b6b8479f6787
出典データセット: uspto-grants-1976_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US03943141

反応ノート

読み込み中…

参加物