3,4,5-Trimethoxybenzaldehyde → 2-Methyl-4-(3',4',5'-trimethoxyphenyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester

HRID 267526

反応式

HRID 267526 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH:6]=O.[CH2:15]([O:17][C:18](=[O:27])[CH2:19][C:20]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=O)[CH3:16].[CH2:28]([O:30][C:31](=[O:36])/[CH:32]=[C:33](\[NH2:35])/[CH3:34])[CH3:29]>C(O)C>[CH2:28]([O:30][C:31]([C:32]1[CH:6]([C:5]2[CH:4]=[C:3]([O:2][CH3:1])[C:10]([O:11][CH3:12])=[C:9]([O:13][CH3:14])[CH:8]=2)[C:19]([C:18]([O:17][CH2:15][CH3:16])=[O:27])=[C:20]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[NH:35][C:33]=1[CH3:34])=[O:36])[CH3:29]

参加物

5

反応物 3

HCID 68583,4,5-TrimethoxybenzaldehydeHCID 66951Diethyl oxalacetateHCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-

生成物 1

HCID 681336892-Methyl-4-(3',4',5'-trimethoxyphenyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

11.8 g of 3,4,5-trimethoxybenzaldehyde, 14 g of oxalacetic acid diethyl ester and 7.8 g of β-aminocrotonic acid ethyl ester in 30 ccs of ethanol are heated to the boil overnight and light yellow crystals of melting point 134° are obtained.

後処理

  1. customare obtained

出典と根拠

ORDレコード
ord-4c15e6d48f364914a68830594d11f9cc
出典データセット
uspto-grants-1976_03
特許番号
US03943140

関連ノート

読み込み中…