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3,4,5-Trimethoxybenzaldehyde → 2-Methyl-4-(3',4',5'-trimethoxyphenyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,4,5-Trimethoxybenzaldehyde | HCID 6858 | — |
| 反応物 | Diethyl oxalacetate | HCID 66951 | — |
| 反応物 | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Methyl-4-(3',4',5'-trimethoxyphenyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester | HCID 68133689 | — |
反応手順
11.8 g of 3,4,5-trimethoxybenzaldehyde, 14 g of oxalacetic acid diethyl ester and 7.8 g of β-aminocrotonic acid ethyl ester in 30 ccs of ethanol are heated to the boil overnight and light yellow crystals of melting point 134° are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03943140 |
| 出典データセット | uspto-grants-1976_03 |
| ORD ID | ord-4c15e6d48f364914a68830594d11f9cc |
| 出典メモ | uspto-grants-1976_03 |