Allyl bromide → HCID 23339063、化合物

HRID 26756

反応式

HRID 26756 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.C(N(CC)CC)C.Br[CH2:32][CH:33]=[CH2:34]>C1C=CC=CC=1>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH:18]2[CH2:23][CH2:22][N:21]([CH2:34][CH:33]=[CH2:32])[CH2:20][CH2:19]2)[C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 7841Allyl bromideHCID 8471TriethylamineHCID 162188N-(4-Chlorophenyl)-N-4-piperidinylbenzeneacetamide

生成物 1

HCID 23339063HCID 23339063、化合物

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

To a stirred solution of 5 parts of N-(4-chlorophenyl)-N-(4-piperidinyl)benzeneacetamide, 3.8 parts of N,N-diethylethanamine in 200 parts of benzene are added portionwise 5 parts of 3-bromo-1-propene. After the addition is complete, the whole is heated for 21 hours at a temperature between 50°-60° C. The reaction mixture is cooled and filtered. The filtrate is washed successively with water, sodium hydrogen carbonate solution and water, dried over potassium carbonate and evaporated. The oily residue is converted into the hydrochloride salt in 1,1'-oxybisethane and 2-propanone, yielding 4 parts of N-(4-chlorophenyl)-N-[1-(2-propenyl)-4-piperidinyl]benzeneacetamide hydrochloride; mp. 225.5° C.

後処理

  1. additionAfter the addition
  2. temperaturethe whole is heated for 21 hours at a temperature between 50°-60° C
  3. temperatureThe reaction mixture is cooled
  4. filtrationfiltered
  5. washThe filtrate is washed successively with water, sodium hydrogen carbonate solution and water
  6. dry with materialdried over potassium carbonate
  7. customevaporated

出典と根拠

ORDレコード
ord-cbff7e24092742ffa2a9ec10e70cf115
出典データセット
uspto-grants-1979_04
特許番号
US04151286

関連ノート

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