2-Indanone → 2-Indanol

HRID 267560

反応式

HRID 267560 の反応式
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[BH4-].[Na+]>CO>[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1[OH:10]

参加物

4

反応物 2

HCID 119832-IndanoneHCID 4311764Sodium borohydride

生成物 1

HCID 779362-Indanol収率 96.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
40 °C

実験手順

A 60 g sample of 2-indanone (0.45 moles) in 1.5 liters of 40% aqueous methanol was treated with 18 g (0.46 moles) of sodium borohydride in portions with cooling to maintain T≤ 40°C. After the addition was complete (15 min), the mixture was stirred for 2 hrs then allowed to stand overnight at room temp. Ether extraction, drying over potassium carbonate and evaporation gave 58.3 g crystalline 2-indanol (96%).

後処理

  1. temperaturewith cooling
  2. additionAfter the addition
  3. custom(15 min)
  4. waitto stand overnight at room temp
  5. extractionEther extraction
  6. dry with materialdrying over potassium carbonate and evaporation

出典と根拠

ORDレコード
ord-6c8acacc781249eebb82cb28dffc8a49
出典データセット
uspto-grants-1976_03
特許番号
US03943149

関連ノート

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