Sulfuric Acid → chrysanthemic acid d-trans-form

反応式

CC[O:3][C:4]([CH:6]1[C:8]([CH3:10])([CH3:9])[CH:7]1[CH:11]=[C:12]([CH3:14])[CH3:13])=[O:5].S(=O)(=O)(O)O>>[CH3:13][C:12]([CH3:14])=[CH:11][C@H:7]1[C:8]([CH3:9])([CH3:10])[C@@H:6]1[C:4]([OH:5])=[O:3]

参加物

反応物 2

HCID 1118Sulfuric Acid

HCID 7334Ethyl chrysanthemate

生成物 1

HCID 16747chrysanthemic acid d-trans-form収率 80.5%

実験手順

The water layer was made acidic with sulfuric acid and extracted with toluene (80 g) two times. The toluene layer was washed and evaporated, and the residue was distilled under reduced pressure to give trans-chrysanthemic acid (47.1 g; trans-isomer, 80.5 %). B.P. 110° to 114°C/2 mmHg.

後処理

extractionextracted with toluene (80 g) two times
washThe toluene layer was washed
customevaporated
distillationthe residue was distilled under reduced pressure

出典と根拠

ORDレコード: ord-3556e4eb9bea4bf1a3c659a1dcdfbbb2
出典データセット: uspto-grants-1976_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US03943167

反応ノート

読み込み中…

参加物