Hydrochloric Acid → HCID 54205932、化合物

反応式

C([NH:4][C:5]1[CH:6]=[C:7]([S:12]([O-:14])=[O:13])[CH:8]=[C:9]([Cl:11])[CH:10]=1)(=O)C.[Na+].[C:16]([O-])(=[O:18])[CH3:17].[K+].Cl[CH:22]([CH2:26]Cl)[C:23](N)=[O:24].Cl>C(O)C>[NH2:4][C:5]1[CH:6]=[C:7]([S:12]([CH:26]=[CH:22][C:23]([O:18][CH2:16][CH3:17])=[O:24])(=[O:13])=[O:14])[CH:8]=[C:9]([Cl:11])[CH:10]=1

参加物

実験手順

2-carbethoxyvinyl 3-amino-5-chlorophenyl sulfone is prepared by reacting sodium 3acetamido-5-chlorobenzenesulfinate in aqueous ethanol solution, in the presence of potassium acetate, with 2,3-dichloropropionamide. The resulting 2-carboxyamidovinyl 3-acetamido-5-chlorophenyl sulfone is hydrolyzed with dilute hydrochloric acid to give 2carboxyamidovinyl 3-amino-5-chlorophenyl sulfone. The dried solid is boiled with ethanol under reflux for 2 hours in the presence of concentrated sulfuric acid. After drowning in water and neutralization 2-carbethoxyvinyl 3-amino-5-chlorophenyl sulfone is obtained.