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N-Phenylhydroxylamine → 1-Trifluoromethyl-3-phenyl-3-hydroxyurea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Phenylhydroxylamine | HCID 7518 | — |
| 反応物 | Pentane | HCID 8003 | — |
| 反応物 | Trifluoromethyl isocyanate | HCID 12494313 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 1-Trifluoromethyl-3-phenyl-3-hydroxyurea | HCID 21553678 | — |
反応手順
A solution of trifluoromethyl isocyanate (11.1 grams, 0.1 mol) in diethyl ether (35 ml) is added dropwise, with stirring to a solution of N-phenyl hydroxylamine (10.9 grams; 0.1 mol) in ether (60 ml) at room temperature. Stirring is continued for a period of about 1 hour resulting in a precipitate. Pentane is added to the mixture to form additional precipitate. The precipitate is then recovered by filtration, is washed and dried to yield 1-trifluoromethyl-3-phenyl-3-hydroxyurea.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03944410 |
| 出典データセット | uspto-grants-1976_03 |
| ORD ID | ord-92f7c705668c44ad969cff59709360de |
| 出典メモ | uspto-grants-1976_03 |