反应详情

A solution of trifluoromethyl isocyanate (11.1 grams, 0.1 mol) in diethyl ether (35 ml) is added dropwise, with stirring to a solution of N-phenyl hydroxylamine (10.9 grams; 0.1 mol) in ether (60 ml) at room temperature. Stirring is continued for a period of about 1 hour resulting in a precipitate. Pentane is added to the mixture to form additional precipitate. The precipitate is then recovered by filtration, is washed and dried to yield 1-trifluoromethyl-3-phenyl-3-hydroxyurea.

1. customresulting in a precipitate
2. customto form additional precipitate
3. filtrationThe precipitate is then recovered by filtration
4. washis washed
5. customdried