Hydrochloric Acid → 2-(Chloromethyl)-2,3-dihydro-1,4-benzodioxin

HRID 267729

反応式

HRID 267729 の反応式
O[CH2:2][CH:3]1[O:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[O:5][CH2:4]1.S(Cl)([Cl:15])=O.Cl>>[Cl:15][CH2:2][CH:3]1[O:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[O:5][CH2:4]1

参加物

4

反応物 3

HCID 313Hydrochloric Acid2 回HCID 193141,4-Benzodioxane-2-methanolHCID 24386Thionyl Chloride

生成物 1

HCID 953202-(Chloromethyl)-2,3-dihydro-1,4-benzodioxin収率 78.6%

実験手順

202 g (1.21 mols) of 2-hydroxymethyl-1,4-benzodioxan are introduced into a 1 liter flask equipped with a stirrer, condenser and dropping funnel, and 288 g (2.42 mols) of thionyl chloride are run in dropwise. Violent evolution of HCl is observed. The mixture is heated under reflux until HCl ceases to be evolved, that is to say for 1 hour 30 minutes. The mixture is then distilled in vacuo after having driven off the excess thionyl chloride. 175.5 g (yield: 77.2%) of 2-chloromethyl-1,4-benzodioxan are obtained.

後処理

  1. customequipped with a stirrer, condenser
  2. temperatureThe mixture is heated
  3. distillationThe mixture is then distilled in vacuo

出典と根拠

ORDレコード
ord-99cf98c2788745b5875395597d4c31fa
出典データセット
uspto-grants-1976_03
特許番号
US03944549

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