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Phosphorus oxychloride → 2-Methoxy-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-YL)-2-pyrrolin-2-YL]phenothiazine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 5-Methyl-2-pyrrolidone | HCID 66055 | — |
| 反応物 | Methyl phenothiazin-2-yl ether | HCID 74490 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | 2-Methoxy-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-YL)-2-pyrrolin-2-YL]phenothiazine hydrochloride | HCID 20307135 | 8.6% |
反応手順
Reaction of 5-methyl-2-pyrrolidinone, 2-methoxyphenothiazine and phosphorus oxychloride in 1,2-dichloroethane according to the procedure of Example 4 affords 2-METHOXY-10-[5-METHYL-1-(5-METHYL-1-PYRROLIN-2-YL)-2-PYRROLIN-2-YL]PHENOTHIAZINE HYDROCHLORIDE (8.6% yield), m.p. 236.5°-238.5° C. (corr.), from ethanol-ether.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03946004 |
| 出典データセット | uspto-grants-1976_03 |
| ORD ID | ord-e2b9cc5433e04e85a624d578ad21690a |
| 出典メモ | uspto-grants-1976_03 |