Chloroacetyl chloride → HCID 12392971、化合物
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]([CH:18]([CH3:20])[CH3:19])[C:10](=[O:21])[NH:9]2)=[CH:4][CH:3]=1.[Cl:22][CH2:23][C:24](Cl)=[O:25].C(N(CC)CC)C>>[CH:18]([CH:11]1[C:12]2[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:8]([C:5]2[CH:4]=[CH:3][C:2]([NH:1][C:24](=[O:25])[CH2:23][Cl:22])=[CH:7][CH:6]=2)[NH:9][C:10]1=[O:21])([CH3:19])[CH3:20]参加物
4
実験手順
10.0 g. (0.0357 moles) of 1-(4'-aminophenyl)-1,4-dihydro-4-isopropyl-3(2H)-isoquinolinone are reacted, in 150 ml. of glacial acid, with 5.07 g. (0.045 moles) of chloroacetyl chloride in the presence of 4.55 g. (0.045 moles) of triethylamine. The reaction conditions are the same as given in Example 1. The crude product is recrystallized from butanol to yield 9.95 g. of the title compound; m.p.: 269°-270°C.
後処理
- customThe reaction conditions