関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 5-Methylpyrazin-2-amine | HCID 313215 | — |
| 反応物 | Sodium Acetate Trihydrate | HCID 23665404 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-Amino-3-bromo-5-methylpyrazine | HCID 9899043 | — |
反応手順
To acetic acid (1500 ml.), 2-amino-5-methylpyrazine (1 mole) and 326.5 g. sodium acetate trihydrate are slowly added 1.1 mole bromine in 180 ml. acetic acid at 2° C. in the absence of light. The mixture is stirred about 15 hours at 20° C., stripped of acetic acid in vacuo, poured into ice, made alkaline with sodium hydroxide, filtered, the residue extracted with ether, the extract stripped and the 2-amino-3-bromo-5-methylpyrazine crystallized from a suitable solvent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US03946009 |
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| 出典データセット | uspto-grants-1976_03 |
|---|
| ORD ID | ord-1bf49bce1db74c0fae2fb1376987c77a |
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| 出典メモ | uspto-grants-1976_03 |
|---|
