反应详情

温度

20 °C

To acetic acid (1500 ml.), 2-amino-5-methylpyrazine (1 mole) and 326.5 g. sodium acetate trihydrate are slowly added 1.1 mole bromine in 180 ml. acetic acid at 2° C. in the absence of light. The mixture is stirred about 15 hours at 20° C., stripped of acetic acid in vacuo, poured into ice, made alkaline with sodium hydroxide, filtered, the residue extracted with ether, the extract stripped and the 2-amino-3-bromo-5-methylpyrazine crystallized from a suitable solvent.

1. customat 2° C.
2. additionpoured into ice
3. filtrationfiltered
4. extractionthe residue extracted with ether
5. customthe 2-amino-3-bromo-5-methylpyrazine crystallized from a suitable solvent