Methanol → 2-Amino-3-n-propoxy-5-methylpyrazine

HRID 267937

反応式

HRID 267937 の反応式
Cl[C:2]1[C:7](Cl)=NC=CN=1.[CH3:9][OH:10].[NH2:11][C:12]1[C:17](Br)=[N:16][C:15]([CH3:19])=[CH:14][N:13]=1>C(O)CC>[NH2:11][C:12]1[C:17]([O:10][CH2:9][CH2:7][CH3:2])=[N:16][C:15]([CH3:19])=[CH:14][N:13]=1

参加物

5

反応物 3

HCID 887MethanolHCID 785752,3-DichloropyrazineHCID 98990432-Amino-3-bromo-5-methylpyrazine

生成物 1

HCID 205289882-Amino-3-n-propoxy-5-methylpyrazine

試薬・触媒・溶媒 1

HCID 10311-Propanol溶媒

実験手順

By replacing the 2,3-dichloropyrazine and anhydrous methanol used in Preparation 43 by equivalent quantities of the product of Step A and n-propanol and following the method described in Preparation 43, 2-amino-3-n-propoxy-5-methylpyrazine is obtained. The 2-amino group can be converted to the 2-hydroxy by the method described by Sharp et al, ibid., (see Route III) which when treated with phosphorus oxychloride by the method of Preparation 13, Step B, provides 2-chloro-3-n-propoxy-5-methylpyrazine.

後処理

  1. customdescribed in Preparation 43

出典と根拠

ORDレコード
ord-420b03f54d664c9d86948acaaa5b44d3
出典データセット
uspto-grants-1976_03
特許番号
US03946009

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