Potassium Carbonate → N-(1,3-dioxolan-5-ylmethyl)-2,6-dimethyl-4-bromoaniline

HRID 268055

反応式

HRID 268055 の反応式
[CH3:1][C:2]1[CH:8]=[C:7]([Br:9])[CH:6]=[C:5]([CH3:10])[C:3]=1[NH2:4].Cl[CH2:12][CH:13]1[O:17][CH2:16][O:15][CH2:14]1.C(=O)([O-])[O-].[K+].[K+]>[Cl-].C([N+](CC)(CC)CC)C>[O:17]1[CH:13]([CH2:12][NH:4][C:3]2[C:2]([CH3:1])=[CH:8][C:7]([Br:9])=[CH:6][C:5]=2[CH3:10])[CH2:14][O:15][CH2:16]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 905494-Bromo-2,6-xylidineHCID 2401534-(Chloromethyl)-1,3-dioxolane

生成物 1

HCID 21447802N-(1,3-dioxolan-5-ylmethyl)-2,6-dimethyl-4-bromoaniline

試薬・触媒・溶媒 1

HCID 5946Tetraethylammonium Chloride触媒

実験手順

2,6-Dimethyl-4-bromoaniline (0.3 mole), 5-chloromethyl-1,3-dioxolane (0.3 mole), potassium carbonate (0.3 mole) and tetraethylammonium chloride (2 grams) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is heated at reflux for a period of 5 hours. After this time the mixture is filtered and distilled to yield the desired product N-(1,3-dioxolan-5-ylmethyl)-2,6-dimethyl-4-bromoaniline.

後処理

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. temperatureThe reaction mixture is heated
  4. temperatureat reflux for a period of 5 hours
  5. filtrationAfter this time the mixture is filtered
  6. distillationdistilled

出典と根拠

ORDレコード
ord-9002f804f96542ec8ebbae79f15c9c38
出典データセット
uspto-grants-1976_03
特許番号
US03946045

関連ノート

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