Potassium Hydroxide → HCID 54053592、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([C:13]#[N:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl.[NH2:16][OH:17].[OH-].[K+]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([C:13](=[N:16][OH:17])[NH2:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1参加物
5
実験手順
A mixture of 51 g (0.25 mole) of 5-(p-chlorophenyl)-2-furonitrile, 19 g (0.27 mole) of hydroxylamine hydrochloride, 18 g (0.27 mole) of potassium hydroxide and 750 ml of absolute ethanol was heated under reflux for 1 hour. The reaction mixture was concentrated on a rotary evaporator and cooled in ice overnight. The solid was collected by filtration and washed with anhydrous ether to give 43 g (73%). Two recrystallizations from absolute ethanol gave an analytical sample, m.p. 167°-169°.
後処理
- temperaturewas heated
- temperatureunder reflux for 1 hour
- concentrationThe reaction mixture was concentrated on a rotary evaporator
- temperaturecooled in ice overnight
- filtrationThe solid was collected by filtration
- washwashed with anhydrous ether
- customto give 43 g (73%)
- customTwo recrystallizations from absolute ethanol
- customgave an analytical sample, m.p. 167°-169°
出典と根拠
- ORDレコード
- ord-2defa1500b5d44f7a748958c70419857
- 出典データセット
- uspto-grants-1976_03
- 特許番号
- US03946049
反応ノート
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