Sodium borohydride → HCID 21553303、化合物

HRID 268093ノート

反応式

HRID 268093 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:14][C:13]([C:15]#[N:16])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[BH4-].[Na+]>O1CCOCC1.O>[OH:3][CH:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]2[O:14][C:13]([C:15]#[N:16])=[CH:12][CH:11]=2)=[CH:8][CH:9]=1)[CH3:2]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 215533215-(4-Acetylphenyl)furan-2-carbonitrile

生成物 1

HCID 21553303HCID 21553303、化合物収率 58%

試薬・触媒・溶媒 1

HCID 218864351,4-Dioxane--water (1/1)溶媒

実験手順

A solution of 46 g (0.22 mole) of 5-(4-acetylphenyl)-2-furonitrile in 800 ml of 95% dioxane/H2O was treated portionwise with 8.3 g (0.22 mole) of NaBH4 while keeping the temperature below 20° by means of an ice bath. The resulting solution was stirred at ambient temperature for 21/2 hours and then added to an ice/H2O mixture. After standing 48 hours, the reaction mixture was extracted with ether and the combined ethereal extracts dried over MgSO4. The ether was removed on the Calab evaporator yielding 27 g (58%) of product as a residual oil.

後処理

  1. customthe temperature below 20°
  2. waitAfter standing 48 hours
  3. extractionthe reaction mixture was extracted with ether
  4. dry with materialthe combined ethereal extracts dried over MgSO4
  5. customThe ether was removed on the Calab evaporator

出典と根拠

ORDレコード
ord-1e4ddf3d09834c9ba1ffe986b44a8551
出典データセット
uspto-grants-1976_03
特許番号
US03946049

反応ノート

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