Cysteamine Hydrochloride → 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride

HRID 26818

反応式

HRID 26818 の反応式
[ClH:1].O[CH2:3][C:4]1[N:5]=[CH:6][NH:7][C:8]=1[CH3:9].Cl.[NH2:11][CH2:12][CH2:13][SH:14]>Cl.C(O)(C)C>[ClH:1].[ClH:1].[CH3:9][C:8]1[N:7]=[CH:6][NH:5][C:4]=1[CH2:3][S:14][CH2:13][CH2:12][NH2:11]

参加物

5

反応物 2

HCID 9082Cysteamine HydrochlorideHCID 30847074-Methylimidazol-5-ylmethanolhydrochloride

生成物 1

HCID 30159992-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride収率 164.7%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 3776Isopropanol溶媒

実験手順

A solution of 4-hydroxymethyl-5-methylimidazole hydrochloride (30.0 g.) and cysteamine hydrochloride (23.0 g.) in concentrated aqueous hydrochloric acid (450 ml.) was heated under reflux for 17 hours. Concentration followed by re-evaporation with water afforded a residue which was dissolved in isopropyl alcohol, concentrated to low bulk and cooled to afford 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride (40.6 g.), m.p. 185°-191°.

後処理

  1. temperatureunder reflux for 17 hours
  2. concentrationConcentration
  3. customfollowed by re-evaporation with water
  4. customafforded a residue which
  5. concentrationconcentrated to low bulk
  6. temperaturecooled

出典と根拠

ORDレコード
ord-2e6aab42d5a84577b0a2369f52c36f5b
出典データセット
uspto-grants-1979_04
特許番号
US04151288

関連ノート

読み込み中…