Hydrochloric Acid → HCID 21551717、化合物

HRID 268215

反応式

HRID 268215 の反応式
[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH:6]=[O:7])([O-:3])=O.[CH3:12][CH:13]1[CH2:18][C:17](=[O:19])[CH2:16][C:15](=O)[CH2:14]1.[ClH:21].O>O1CCCC1>[Cl:21][C:9]1[CH:8]=[C:5]2[C:4]([N:1]([OH:3])[C:15]3[CH2:14][CH:13]([CH3:12])[CH2:18][C:17](=[O:19])[C:16]=3[C:6]2=[O:7])=[CH:11][CH:10]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 111012-NitrobenzaldehydeHCID 4580955-Methylcyclohexane-1,3-dione

生成物 1

HCID 21551717HCID 21551717、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

30.2 g (0.2 mole) of 2-nitrobezaldehyde and 25.2 g (0.2 mole) of 5-methyl-1,3-cyclohexane-dione were dissolved in 300 ml of tetrahydrofurane, the solution was saturated at 18° C with hydrogen chloride and allowed to stand for 4 days at room temperature. Water was added, the oily layer was separated and stirred with methanol. The crystals that had formed were filtered off, washed with methanol and dissolved and recrystallized from glacial acetic acid. 9.5 g (17 % of the theory) of 7-chloro-3-methyl-10-hydroxy-1-oxo-1,2,3,4-tetrahydro-9(10H)-acridone having a decomposition point of 255° C were obtained.

後処理

  1. customthe oily layer was separated
  2. customThe crystals that had formed
  3. filtrationwere filtered off
  4. washwashed with methanol
  5. dissolutiondissolved
  6. customrecrystallized from glacial acetic acid

出典と根拠

ORDレコード
ord-b7b28e330e6243c899d66b4fb4eab0ff
出典データセット
uspto-grants-1976_03
特許番号
US03947449

関連ノート

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