Formaldehyde → (3,4-dihydro-2(1H)-isoquinolinylmethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione

HRID 268240

反応式

HRID 268240 の反応式
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][NH:2]1.[CH2:11]=O.[CH:13]1[CH:14]=[C:15]2[C:20]3=[C:21]([C:23]([NH:25][C:26](=[O:27])[C:19]3=[CH:18][CH:17]=[CH:16]2)=[O:24])[CH:22]=1>CN(C)C=O>[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[CH2:11][N:25]1[C:26](=[O:27])[C:19]2[CH:18]=[CH:17][CH:16]=[C:15]3[C:20]=2[C:21](=[CH:22][CH:13]=[CH:14]3)[C:23]1=[O:24]

参加物

5

反応物 3

HCID 712FormaldehydeHCID 70461,2,3,4-TetrahydroisoquinolineHCID 66491Naphthalimide

生成物 1

HCID 21551797(3,4-dihydro-2(1H)-isoquinolinylmethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

An equimolar mixture of 1,2,3,4-tetrahydroisoquinoline, aqueous formaldehyde, and 1,8-naphthalimide is suspended in a small amount of dimethylformamide and the mixture is heated until dissolution is complete. The solution is allowed to stand at room temperature and the resulting precipitate is filtered off and dried to yield 2-[(3,4-dihydro-2(1H)-isoquinolinylmethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione.

後処理

  1. temperaturethe mixture is heated until dissolution
  2. customto stand at room temperature
  3. filtrationthe resulting precipitate is filtered off
  4. customdried

出典と根拠

ORDレコード
ord-86ae842f9f6b4d99be980a88a6d2904a
出典データセット
uspto-grants-1976_03
特許番号
US03947452

関連ノート

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