Hydrochloric Acid → N-methyl-N'-[2-((2-amino-4-imidazolyl)methylthio)ethyl]thiourea

HRID 26830

反応式

HRID 26830 の反応式
Cl.NC1NC=C(CO)N=1.C1(C([O-])=C([N+]([O-])=O)C=C([N+]([O-])=O)C=1)[N+]([O-])=O.Cl.Cl.NCCS.[NH2:32][C:33]1[NH:34][CH:35]=[C:36]([CH2:38][S:39][CH2:40][CH2:41][NH2:42])[N:37]=1.[CH3:43][N:44]=[C:45]=[S:46]>>[CH3:43][NH:44][C:45]([NH:42][CH2:41][CH2:40][S:39][CH2:38][C:36]1[N:37]=[C:33]([NH2:32])[NH:34][CH:35]=1)=[S:46]

参加物

7

反応物 6

HCID 313Hydrochloric AcidHCID 9082Cysteamine HydrochlorideHCID 11167Methyl isothiocyanateHCID 4432340PicrateHCID 178479151HCID 178479151、化合物HCID 178511470HCID 178511470、化合物

生成物 1

HCID 178486118N-methyl-N'-[2-((2-amino-4-imidazolyl)methylthio)ethyl]thiourea

実験手順

Reaction of 2-amino-4-hydroxymethylimidazole hydrochloride (which is obtained by treating the picrate salt with hydrochloric acid) with cysteamine hydrochloride and reaction of the resulting 2-amino-4-[(2-aminoethyl)thiomethyl]imidazole with methyl isothiocyanate by the methods of Example 1 gives N-methyl-N'-[2-((2-amino-4-imidazolyl)methylthio)ethyl]thiourea.

後処理

  1. customis obtained

出典と根拠

ORDレコード
ord-a98ca8b2a24d4862b7388c20e6e70c8f
出典データセット
uspto-grants-1979_04
特許番号
US04151288

関連ノート

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