Methyl Ethyl Ketone → 3-[4-(3-Di-n-butylaminopropoxy)benzoyl]-2-phenylbenzofuran

HRID 268343

反応式

HRID 268343 の反応式
[OH:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([C:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[O:10][C:9]=2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:7])=[CH:4][CH:3]=1.[CH2:25]([N:29]([CH2:34][CH2:35][CH2:36][CH3:37])[CH2:30][CH2:31][CH2:32]Cl)[CH2:26][CH2:27][CH3:28].C(=O)([O-])[O-].[K+].[K+].CC(=O)CC>CCOCC.O>[CH2:34]([N:29]([CH2:25][CH2:26][CH2:27][CH3:28])[CH2:30][CH2:31][CH2:32][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[O:10][C:9]=2[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:7])=[CH:23][CH:24]=1)[CH2:35][CH2:36][CH3:37]

参加物

7

反応物 4

HCID 6569Methyl Ethyl KetoneHCID 11430Potassium CarbonateHCID 96084N-(3-Chloropropyl)dibutylamineHCID 13264991(4-Hydroxyphenyl)(2-phenyl-1-benzofuran-3-yl)methanone

生成物 1

HCID 214353183-[4-(3-Di-n-butylaminopropoxy)benzoyl]-2-phenylbenzofuran

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 2.0 g. (6.4 mmol.) of 3-(4-hydroxybenzoyl)-2-phenylbenzofuran, 1.3 g. (6.4 mmol.) of 3-di-n-butylaminopropyl chloride and 4.0 g. (0.04 mol.) of anhydrous potassium carbonate in 20 ml. of dry 2-butanone is refluxed for 18 hours. The reaction is cooled, water and ether are added and the layers are separated. The organic phase is extracted with 10% aqueous sodium hydroxide and the aqueous layers are combined and extracted again with water. The combined ether extracts are concentrated under reduced pressure to give the title compound.

後処理

  1. additionA mixture of 2.0 g
  2. temperatureThe reaction is cooled
  3. customthe layers are separated
  4. extractionThe organic phase is extracted with 10% aqueous sodium hydroxide
  5. extractionextracted again with water
  6. concentrationThe combined ether extracts are concentrated under reduced pressure

出典と根拠

ORDレコード
ord-53826219a097465b97c761cc54cc0b80
出典データセット
uspto-grants-1976_03
特許番号
US03947470

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