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Methyl Ethyl Ketone → 3-[4-(3-Di-n-butylaminopropoxy)benzoyl]-2-phenylbenzofuran
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Ethyl Ketone | HCID 6569 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | N-(3-Chloropropyl)dibutylamine | HCID 96084 | — |
| 反応物 | (4-Hydroxyphenyl)(2-phenyl-1-benzofuran-3-yl)methanone | HCID 13264991 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 3-[4-(3-Di-n-butylaminopropoxy)benzoyl]-2-phenylbenzofuran | HCID 21435318 | — |
反応手順
A mixture of 2.0 g. (6.4 mmol.) of 3-(4-hydroxybenzoyl)-2-phenylbenzofuran, 1.3 g. (6.4 mmol.) of 3-di-n-butylaminopropyl chloride and 4.0 g. (0.04 mol.) of anhydrous potassium carbonate in 20 ml. of dry 2-butanone is refluxed for 18 hours. The reaction is cooled, water and ether are added and the layers are separated. The organic phase is extracted with 10% aqueous sodium hydroxide and the aqueous layers are combined and extracted again with water. The combined ether extracts are concentrated under reduced pressure to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03947470 |
| 出典データセット | uspto-grants-1976_03 |
| ORD ID | ord-53826219a097465b97c761cc54cc0b80 |
| 出典メモ | uspto-grants-1976_03 |