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Phenylacetonitrile → Ethyl 3-cyano-3-phenylpyruvate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenylacetonitrile | HCID 8794 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | Ethanedioic acid, monoethyl ester | HCID 21943339 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Ethyl 3-cyano-3-phenylpyruvate | HCID 22845 | — |
反応手順
A mixture of 117.1 g. (1.0 mol.) of phenylacetonitrile and 326 ml. (2.4 mol.) of ethyl oxalate was added to an ethanol solution of sodium ethoxide [prepared by dissolving 23.8 g. (1.08 g. -atom) of sodium in 500 ml. of absolute ethanol] and refluxed for two hours. After cooling, diluting with 2500 ml. of water and extracting with ether, the solution was acidified with acetic acid. The solid was removed by filtration and washed with water to give ethyl 3-cyano-3-phenylpyruvate, m.p. 127°-129°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03947580 |
| 出典データセット | uspto-grants-1976_03 |
| ORD ID | ord-4f04b52743454e7e8f44473e9b3dc849 |
| 出典メモ | uspto-grants-1976_03 |