反应详情

A mixture of 117.1 g. (1.0 mol.) of phenylacetonitrile and 326 ml. (2.4 mol.) of ethyl oxalate was added to an ethanol solution of sodium ethoxide [prepared by dissolving 23.8 g. (1.08 g. -atom) of sodium in 500 ml. of absolute ethanol] and refluxed for two hours. After cooling, diluting with 2500 ml. of water and extracting with ether, the solution was acidified with acetic acid. The solid was removed by filtration and washed with water to give ethyl 3-cyano-3-phenylpyruvate, m.p. 127°-129°.

1. additionA mixture of 117.1 g
2. temperaturerefluxed for two hours
3. temperatureAfter cooling
4. additiondiluting with 2500 ml
5. extractionof water and extracting with ether
6. customThe solid was removed by filtration
7. washwashed with water