Benzoyl Peroxide → HCID 21413805、化合物

HRID 268489ノート

反応式

HRID 268489 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[O:10][C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)[CH:5]=[CH:6][C:7]=1[CH3:8].[Br:18]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:18][CH2:8][C:7]1[CH:6]=[CH:5][C:4]([C:9]2[O:10][C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)=[CH:3][C:2]=1[F:1]

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 214137972-(3-Fluoro-4-methylphenyl)benzoxazole

生成物 1

HCID 21413805HCID 21413805、化合物

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

To a solution of 5.1 gm. of 2-(3-fluoro-4-methyl-phenyl) benzoxazole in 60 ml. of carbon tetrachloride is added 6.23 gm. N-bromosuccinimide and 100 mg. of dibenzoyl peroxide. The reaction mixture is refluxed for 6 hours, filtered to remove succinimide and the filtrate concentrated to dryness. The residue is chromatographed on 500 gm. of silica gel. Elution with 1% ether in petroleum ether gives 2-(4-bromomethyl-3-fluorophenyl)benzoxazole, m.p. 150°-152°C.

後処理

  1. temperatureThe reaction mixture is refluxed for 6 hours
  2. filtrationfiltered
  3. customto remove succinimide
  4. concentrationthe filtrate concentrated to dryness
  5. customThe residue is chromatographed on 500 gm
  6. washElution with 1% ether in petroleum ether

出典と根拠

ORDレコード
ord-ba5d44adee69425e84f73f2915889f5a
出典データセット
uspto-grants-1976_03
特許番号
US03947582

反応ノート

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