Hydrochloric Acid → 5,7-Dimethylindole

HRID 268676ノート

反応式

HRID 268676 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([CH3:11])[CH:10]=1)[NH:7][C:6](=O)[C:5]2=O.Cl.C(=O)(O)[O-].[Na+]>O1CCCC1>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([CH3:11])[CH:10]=1)[NH:7][CH:6]=[CH:5]2

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 382965,7-dimethyl-2,3-dihydro-1H-indole-2,3-dioneHCID 516892Sodium Bicarbonate

生成物 1

HCID 5893955,7-Dimethylindole

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To solution of 5,7-dimethyl-1H-indole-2,3-dione in tetrahydrofuran at 0° C. was added 1.0 M solution of borane-tetrahydrofuran complex in tetrahydrofuran (40 mL). After stirred at room temperature overnight, a 5% HCl solution was added to the mixture and it was stirred 20 minutes. It was neutralized with saturated sodium bicarbonate solution and extracted with ethyl acetate. Extracts were dried over magnesium sulfate and evaporated to dryness to afford the title compound as oil.

後処理

  1. stirringwas stirred 20 minutes
  2. extractionextracted with ethyl acetate
  3. dry with materialExtracts were dried over magnesium sulfate
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-df40a1c683f744a0950f484c0ecc2580
出典データセット
uspto-grants-2008_11
特許番号
US07446122B2

反応ノート

読み込み中…