Thionyl Chloride → 4-(3-Piperidin-1-yl-propoxy)-2-trifluoromethyl-benzoyl chloride

反応式

[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:19]=[CH:18][C:14]([C:15](O)=[O:16])=[C:13]([C:20]([F:23])([F:22])[F:21])[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:26])=O>>[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:19]=[CH:18][C:14]([C:15]([Cl:26])=[O:16])=[C:13]([C:20]([F:23])([F:22])[F:21])[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 179863184-(3-Piperidin-1-yl-propoxy)-2-trifluoromethyl-benzoic acid

生成物 1

HCID 179862554-(3-Piperidin-1-yl-propoxy)-2-trifluoromethyl-benzoyl chloride

実験手順

4-(3-Piperidin-1-yl-propoxy)-2-trifluoromethyl-benzoic acid (D5) (0.9 g) was heated at reflux in thionyl chloride (20 ml) for 2 h. The reaction mixture was evaporated to a minimum then co-evaporated with DCM (3×) to give the title compound (D6) as a white solid (1.0 g)

後処理

customThe reaction mixture was evaporated to a minimum

出典と根拠

ORDレコード: ord-54dc54d50e2942f4a9bfbaceef46e2b1
出典データセット: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07446103B2

反応ノート

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