Trifluoroacetic acid → 5-Cyanoisoindoline trifluoroacetate
反応式
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:17]#[N:18])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[C:19]([OH:25])([C:21]([F:24])([F:23])[F:22])=[O:20]>C(Cl)Cl>[F:22][C:21]([F:24])([F:23])[C:19]([OH:25])=[O:20].[C:17]([C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:16]2)#[N:18]参加物
4
実験手順
A solution of N-t-butoxycarbonyl-5-cyanoisoindoline (D15) (130 mg) in DCM (3 ml) at rt was treated with TFA (1 ml) and after 1 h it was evaporated. The residue was re-evaporated from MeOH/toluene to give the title compound (D16) (140 mg). 1H NMR δ (CDCl3): 7.70 (2H, m), 7.50 (1H, m), 4.75 (4H, m).
後処理
- customwas evaporated
- customThe residue was re-evaporated from MeOH/toluene
出典と根拠
- ORDレコード
- ord-23a5ec05c1184be59fb21a0ec0c3e633
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07446103B2
反応ノート
読み込み中…