4-[(1-Cyclobutyl-4-piperidinyl)oxy]benzoic acid hydrochloride → 4-[(1-Cyclobutyl-4-piperidinyl)oxy]benzoyl chloride hydrochloride
反応式
[ClH:1].[CH:2]1([N:6]2[CH2:11][CH2:10][CH:9]([O:12][C:13]3[CH:21]=[CH:20][C:16]([C:17](O)=[O:18])=[CH:15][CH:14]=3)[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3]1>S(Cl)(Cl)=O>[ClH:1].[CH:2]1([N:6]2[CH2:11][CH2:10][CH:9]([O:12][C:13]3[CH:21]=[CH:20][C:16]([C:17]([Cl:1])=[O:18])=[CH:15][CH:14]=3)[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3]1参加物
3
実験手順
4-[(1-Cyclobutyl-4-piperidinyl)oxy]benzoic acid hydrochloride (D24) (0.20 g) was dissolved in thionyl chloride (10 ml) and heated under reflux for 1.5 h. The thionyl chloride was removed by evaporation and the residue evaporated from DCM (3×10 ml) to give the title compound (D25) (0.21 g).
後処理
- temperatureheated
- temperatureunder reflux for 1.5 h
- customThe thionyl chloride was removed by evaporation
- customthe residue evaporated from DCM (3×10 ml)
出典と根拠
- ORDレコード
- ord-8b8a52be8c1d4fc3b57053cbe9915615
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07446103B2
反応ノート
読み込み中…