2-Chloro-4-[(1-isopropyl-4-piperidinyl)oxy]benzoic acid hydrochloride → 2-Chloro-4-[(1-isopropyl-4-piperidinyl)oxy]benzoyl chloride hydrochloride
反応式
[ClH:1].[Cl:2][C:3]1[CH:11]=[C:10]([O:12][CH:13]2[CH2:18][CH2:17][N:16]([CH:19]([CH3:21])[CH3:20])[CH2:15][CH2:14]2)[CH:9]=[CH:8][C:4]=1[C:5](O)=[O:6]>S(Cl)(Cl)=O>[ClH:2].[Cl:2][C:3]1[CH:11]=[C:10]([O:12][CH:13]2[CH2:18][CH2:17][N:16]([CH:19]([CH3:21])[CH3:20])[CH2:15][CH2:14]2)[CH:9]=[CH:8][C:4]=1[C:5]([Cl:1])=[O:6]参加物
3
実験手順
2-Chloro-4-[(1-isopropyl-4-piperidinyl)oxy]benzoic acid hydrochloride (D32) (0.20 g) was dissolved in thionyl chloride (10 ml) and heated under reflux for 1.5 h. The thionyl chloride was removed by evaporation and the residue was evaporated from DCM (3×10 ml) to give the title compound (D33) (0.21 g).
後処理
- temperatureheated
- temperature