3-(5-Methoxy-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester → 3-(5-Methoxy-1H-Indol-4-yl)-3-phenyl-propionic acid ethyl ester

HRID 268786ノート

反応式

HRID 268786 の反応式
[CH2:1]([O:3][C:4](=[O:24])[CH:5]=[C:6]([C:13]1[C:21]([O:22][CH3:23])=[CH:20][CH:19]=[C:18]2[C:14]=1[CH:15]=[CH:16][NH:17]2)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:2]>CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:24])[CH2:5][CH:6]([C:13]1[C:21]([O:22][CH3:23])=[CH:20][CH:19]=[C:18]2[C:14]=1[CH:15]=[CH:16][NH:17]2)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:2]

参加物

4

反応物 1

HCID 673557843-(5-Methoxy-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester

生成物 1

HCID 598318913-(5-Methoxy-1H-Indol-4-yl)-3-phenyl-propionic acid ethyl ester

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 3-(5-Methoxy-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester XLVIII (37 mg, 0.115 mmol) in EtOH (4 ml) and a catalytic amount of Degoussa-type catalyst Pd/C wet (10%) was subjected to hydrogenation conditions in a Parr apparatus at 60 psi of H2 for 20 hours. The reaction mixture was filtered through celite with MeOH. The filtrate was concentrated and subjected to the same hydrogenation conditions for 24 hours to provide 3-(5-Methoxy-1H-Indol-4-yl)-3-phenyl-propionic acid ethyl ester XLIX (37 mg) as a yellow oil.

後処理

  1. filtrationThe reaction mixture was filtered through celite with MeOH
  2. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-5cef03c1bb904c5eac4b9a04f46b1568
出典データセット
uspto-grants-2008_11
特許番号
US07446118B2

反応ノート

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